Embodiments are disclosed for generating a lookup table value for calibrating a lookup table circuit in an optical transmitter. The example method includes generating a calibration signal. The calibration signal encodes a plurality of bits in a number of amplitude levels. The example method further includes transmitting the calibration signal to a module under calibration and transmitting a symbol sequence of defined length to a reference module. The reference module compares the symbol sequence with a distorted signal received from the module under calibration to generate a set of condition count statistics. The example method further includes receiving the set of condition count statistics from the receiver in the reference module and calculating a lookup table value based on the set of condition count statistics. The example method further includes transmitting the lookup table value to a transmitter associated with the module under calibration.