Provided are an apparatus, computer program product, system, and method for managing multiple regions of a non-volatile memory device. A first group of logical bands is assigned to a first memory region in which metadata will be stored and a second group of logical bands is assigned to a second memory region to which host data is written, wherein the second group of logical bands is larger than the first group of logical bands. Physical bands are mapped to the first number of logical bands and the second number of logical bands. Indication is returned to the host system of the first and second groups of logical bands assigned to the first and second memory regions, respectively. The host system directs requests for metadata to logical addresses in the first group of logical bands and directs request for file data to logical addresses in the second group of logical bands.