A motor drive circuit includes a first serializer-deserializer (SER-DES) module that converts first SER-DES input signals into a first SER-DES output serial data stream. The first SER-DES input signals relate to motor control inputs or motor drive power outputs. A second SER-DES module converts a second SER-DES input serial data stream corresponding to the first SER-DES output serial data stream into second SER-DES output signals. The second SER-DES input signals relate to motor drive power outputs or motor control inputs. A serial isolation channel provides a galvanic isolation barrier between the first SER-DES module and the second SER-DES module. The serial isolation channel communicates the first SER-DES output serial data stream across the galvanic isolation barrier to provide the second SER-DES input serial data stream.