- 专利标题： Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids
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申请号： US16149025申请日： 2018-10-01
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公开(公告)号： US10544420B2公开(公告)日： 2020-01-28
- 发明人: Christina D. Smolke , Derek H. Wells
- 申请人： Antheia, Inc.
- 申请人地址： US CA Menlo Park
- 专利权人： Antheia, Inc.
- 当前专利权人： Antheia, Inc.
- 当前专利权人地址： US CA Menlo Park
- 代理机构： Wilson Sonsini Goodrich & Rosati
- 主分类号： C12N15/22
- IPC分类号： C12N15/22 ; C12N9/06 ; C12P17/18 ; C12P17/12 ; C12N15/62 ; C12N9/02 ; C12N9/90 ; C12N15/52
摘要：
The present disclosure provides systems and methods for increasing production of an alkaloid product through the epimerization of a (S)-1-benzylisoquinoline alkaloid to a (R)-1-benyzlisoquinoline alkaloid via an engineered epimerase in an engineered host cell. A (S)-1-benzylisoquinoline alkaloid is contacted with said engineered epimerase. Contacting said (S)-1-benzylisoquinoline alkaloid with said engineered epimerase converts said (S)-1-benzylisoquinoline alkaloid to said (R)-1-benzylisoquinoline alkaloid.
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