The invention provides an ESD (Electrostatic Discharge) protection circuit including a clamp circuit, a switch element, and a detection circuit. The clamp circuit is coupled between an ESD bus and a ground node. The switch element is coupled between a supply node and the ESD bus. The detection circuit is configured to detect whether an ESD event occurs. When no ESD event occurs, the detection circuit closes the switch element, such that the ESD bus is coupled to the supply node. When the ESD event occurs, the detection circuit opens the switch element, such that the ESD bus is decoupled from the supply node.