A rotor spinning machine includes a plurality of work stations arranged side by side between two front-side ends along at least one longitudinal side of the machine. Each work station includes work elements for producing and winding a yarn, such as a feed device, an opening device, a spinning rotor, and a winding device. A suction device provides a negative spinning pressure at the work stations and includes a negative pressure source arranged at each of the two front-side ends of the rotor spinning machine. Each negative pressure source is connected to a separate negative pressure channel that extends in a longitudinal direction of the rotor spinning machine only over a part of a total number of the work stations. Each work station includes an individual drive for the spinning rotor.