发明授权
- 专利标题: Glucose derivative, and cell imaging method and imaging agent using said derivative
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申请号: US15956897申请日: 2018-04-19
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公开(公告)号: US10509041B2公开(公告)日: 2019-12-17
- 发明人: Katsuya Yamada , Ayako Sasaki , Tadashi Teshima , Toshihiro Yamamoto , Yuji Otsuka
- 申请人: HIROSAKI UNIVERSITY
- 申请人地址: JP Hirosaki-Shi, Aomori
- 专利权人: HIROSAKI UNIVERSITY
- 当前专利权人: HIROSAKI UNIVERSITY
- 当前专利权人地址: JP Hirosaki-Shi, Aomori
- 代理机构: Buchanan, Ingersoll & Rooney PC
- 优先权: JP2014-079071 20140408
- 主分类号: G01N33/66
- IPC分类号: G01N33/66 ; C07H17/075 ; C07H19/04 ; A61K49/00 ; A61K51/04 ; C07H17/02 ; G01N33/574 ; G01N33/58
摘要:
Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided is a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.
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