- 专利标题： Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof
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申请号： US15654662申请日： 2017-07-19
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公开(公告)号： US10508122B2公开(公告)日： 2019-12-17
- 发明人: Xuedong Liu , Gan Zhang , Daniel Chuen-Fong Chan , Anthony D. Piscopio
- 申请人： The Regents of the University of Colorado, A Body Corporate
- 申请人地址： US CO Denver
- 专利权人： The Regents of the University of Colorado, A Body Corporate
- 当前专利权人： The Regents of the University of Colorado, A Body Corporate
- 当前专利权人地址： US CO Denver
- 代理机构： Morgan, Lewis & Bockius LLP
- 主分类号： C07D513/04
- IPC分类号： C07D513/04 ; C07D473/34 ; C07D487/04 ; C07D473/16
摘要：
The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
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