A device for clearing obstructions from a medical tube includes an enclosure having an interior and an exterior, the enclosure comprising a distal opening for providing access to the interior of the enclosure. The device further includes a spool provided within the enclosure that is rotatable about an axis and an elongated guide member coupled to the spool such that rotation of the spool causes the guide member to wind or unwind about the spool. The device further includes a drive mechanism that is operable to rotate the spool within the enclosure without compromising a sterile field within the enclosure.