Invention Grant
- Patent Title: Pharmacologically active compounds
-
Application No.: US15953109Application Date: 2018-04-13
-
Publication No.: US10442814B2Publication Date: 2019-10-15
- Inventor: Martin Leuwer , Paul M. O'Neill , Neil Berry , Chandrakala Pidathala
- Applicant: The University of Liverpool
- Applicant Address: GB Liverpool
- Assignee: University of Liverpool
- Current Assignee: University of Liverpool
- Current Assignee Address: GB Liverpool
- Agency: Foley Hoag LLP
- Agent David P. Halstead; Lucas P. Watkins
- Priority: GB1322905.9 20131223
- Main IPC: C07D491/107
- IPC: C07D491/107 ; C07D205/04 ; C07D265/30 ; C07D493/10 ; C07D295/192 ; C07D211/06 ; A61P25/00 ; A61P23/00

Abstract:
The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
Public/Granted literature
- US20190084993A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS Public/Granted day:2019-03-21
Information query