This invention is an apparatus for physically enclosing access ports on intravenous (IV) tubing to defend against bacterial contamination. In one configuration, the invention encapsulates an IV manifold and contains a sliding door mechanism to allow access to the ports. In another configuration, the invention covers an individual access port and contains a flip-top cap to allow access to the port. In either configuration, a chemical solution can optionally be included on either the cushioned strip or the cushioned disc to provide additional bacterial protection to the ports.