- 专利标题： TGF beta receptor antagonists
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申请号： US15747843申请日： 2016-07-27
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公开(公告)号： US10399987B2公开(公告)日： 2019-09-03
- 发明人: Lalgudi S. Harikrishnan , Brian E. Fink , Robert M. Borzilleri , Gopikishan Tonukunuru , Jayakumar Sankara Warrier
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myer Squibb Company
- 当前专利权人： Bristol-Myer Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Elliott Korsen
- 国际申请： PCT/US2016/044233 WO 20160727
- 国际公布： WO2017/019757 WO 20170202
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61P35/00 ; A61K31/519
摘要：
The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
公开/授权文献
- US20180215762A1 TGF BETA RECEPTOR ANTAGONISTS 公开/授权日：2018-08-02
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