An actuation system for at least one hydraulically actuatable device, e.g., a vehicle brake, may include an actuation device, e.g., a brake pedal, at least one first pressure source that can be actuated using the actuation device, and a second pressure source having a pressure-generating arrangement that is moveable in two directions, and which includes an electro-mechanical drive for the pressure-generating arrangement. Each pressure source is connected via at least one hydraulic line to the hydraulically actuatable device for supplying pressurizing medium. A valve device may regulate pressure of the hydraulically actuatable device. Pressurizing medium can be supplied in a controlled manner in both movement directions of the pressure-generating arrangement. Provision is made for two working chambers of the second pressure source to be connected by a hydraulic line, and a valve device may be arranged in the hydraulic line.