A color filter substrate is disclosed, including a substrate, a black matrix disposed on the substrate and multiple color resist blocks separated by the black matrix and disposed on the substrate. Each color resist block is filled with a color resist material, the color resist material includes pigment molecules, including at least one photosensitive substituent. A liquid crystal display device having the same is also disclosed. Utilizing an UV irradiation step in the CF process, the pigment molecules are aligned directionally, which can increase the transmittance of the color filter substrate, the utilization rate of the backlight, and decrease the power consumption. Under the same display brightness, the thickness of the color filter substrate can be decreased; the pigment molecules aligned directionally can make an emitting light to be along a same direction to reduce the light interference between adjacent sub-pixels having different colors to greatly decrease the color shift.