Methods and structures for improved isolation in a SiGe BiCMOS process or a CMOS process are provided. In one method, shallow trench isolation (STI) regions are formed in a first semiconductor region located over a semiconductor substrate. Dummy active regions of the first semiconductor region extend through the STI regions to an upper surface of the first semiconductor region. A grid of deep trench isolation (DTI) regions is also formed in the first semiconductor region, wherein the DTI regions extend entirely through the first semiconductor region. The grid of DTI regions includes a pattern that exhibits only T-shaped or Y-shaped intersections. The pattern defines a plurality of openings, wherein a dummy active region is located within each of the openings.