- 专利标题： Oncostatin M (OSM) antagonists for preventing cancer metastasis and IL-6 related disorders
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申请号： US15403965申请日： 2017-01-11
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公开(公告)号： US10286070B2公开(公告)日： 2019-05-14
- 发明人: Cheryl Jorcyk , Dong Xu
- 申请人： Cheryl Jorcyk , Dong Xu
- 申请人地址： US ID Boise US ID Pocatello
- 专利权人： Boise State University,Idaho State University
- 当前专利权人： Boise State University,Idaho State University
- 当前专利权人地址： US ID Boise US ID Pocatello
- 代理机构： McKee, Voorhees & Sease, PLC
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/165 ; A61K31/36 ; A61K31/404 ; A61K31/427 ; A61K31/473 ; A61K31/513 ; A61K31/522 ; A61K31/53 ; C07K16/24 ; A61K45/06 ; A61K31/4025 ; A61K31/4178 ; A61K31/4184 ; A61K39/00
摘要：
A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, proliferation and metastasis in several cancer types.
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