Spectral imaging sensors and methods are disclosed. One spectral imaging sensor includes a light source, an array of coded apertures, one or more optical elements, and a photodetector. The light source is configured to emit a plurality of pulses of light toward an object to be imaged. The array of coded apertures is positioned to spatially modulate light received from the object to be imaged. The optical elements are configured to redirect light from the array of coded apertures. The photodetector is positioned to receive light from the one or more optical elements. The photodetector comprise a plurality of light sensing elements. The plurality of light sensing elements are operable to sense the light from the one or more optical elements in a plurality of time periods. The plurality of time periods have a same frequency as the plurality of pulses of light.