A two-stage air boosting system for an internal combustion engine has a first air boosting system which is one of an electrical air boosting system or a turbocharger air boosting system. The two-stage air boosting system also includes a second air boosting system which is the other one of the electrical air boosting system or the turbocharger air boosting system and is positioned intermediate the first air boosting system and an air intake manifold of the internal combustion engine. A plurality of sensors provides information relating to operation of the two-stage air boosting system including inlet conditions of a compressor of the second air boosting system. A control module is configured to receive a plurality of inputs including the information relating to operation of the two-stage air boosting system, and is further configured to provide a system control command for the two-stage air boosting system responsive to the inputs.