The utility model discloses an anti-pressure packaging box which comprises a bottom plate, a first top plate, a second top plate, a first side plate and a second side plate, wherein the first side plate is connected between the first top plate and the bottom plate; the second side plate is connected between the second top plate and the bottom plate; the anti-pressure packaging box is internally provided with a framework used for containing medicaments; the framework is positioned on the second top plate; the internal surface of the bottom plate is provided with four support devices for supporting the second top plate; the heights of the support devices are equal and are within a range of 5-6cm; the support devices are of a triangular pyramid shape; and the four support devices are arranged in a square shape. The support devices in the anti-pressure packaging box play a role in supporting, so that the anti-pressure medicament packaging box is prevented from deforming under a pressed condition, and the anti-pressure packaging box is simple in structure and low in manufacturing cost.