The utility model discloses a device for skin disinfection before injection. The device for skin disinfection before injection comprises a bottle (1) which comprises a clear water chamber (4) and an iodine chamber (5), wherein the clear water chamber (4) and the iodine chamber (5) are hermetically partitioned through a partition wall (6) between the clear water chamber (4) and the iodine chamber (5). The upper end of each of the clear water chamber (4) and the iodine chamber (5) is provided with a connection column (8) which is detachable, each connection column (8) is provided with a wiping head (2), and each wiping head (2) is connected with an immersion liquid cavity (3) in the corresponding connection column (8). The device for skin disinfection before injection is simple in structure and convenient to carry, and utilization efficiency is improved as a step of liquid dipping is omitted. Further, the skin is cleaned by being wiped with clean water before being wiped with disinfection iodine, so that disinfection effect is promoted.