The invention discloses a fusing gene of mammary specificity, which comprises the following parts from 5' to 3': 5' flank sequence of cow beta-lactoglobulin, human lysyme gene and 3' flank sequence of cow anterior pituitary growth hormone. The invention also provides the making method of gene-transmitting animal, which comprises the following steps: transmitting to infect cell through fusing celland resistant sieved gene; obtaining transmitted gene cell with entire fusing gene in the genome; cloning cell based on transmitted gene cell as core supplier; obtaining animal to produce human lysyme.