知搜-全球专利检索

  1. 登录
  2. 注册
发明授权
CN1927197B 1β-氧代-5,11(13)-二烯桉烷-12-酸抑制乙肝病毒药物的制药用途 失效 - 权利终止

1β-氧代-5,11(13)-二烯桉烷-12-酸抑制乙肝病毒药物的制药用途
摘要：
本发明涉及一种具有式(1)所示结构之1β-氧代-5，11(13)-二烯桉烷-12-酸及其可药用盐或溶剂化物及其药物组合物在降低乙型肝炎表面抗原和抑制乙肝病毒HBVDNA复制活性的医药用途。本发明化合物对HepG2.2.15细胞分泌的乙型肝炎表面抗源(HBsAg)和乙肝病毒脱氧核糖核酸(HBV-DNA)的复制具有较强的抑制作用，其抑制HBsAg能力在同一剂量超过阳性对照拉米呋啶；其在100μg/mL、20μg/mL和4μg/mL浓度时对乙肝病毒HBV-DNA的复制部有明显的抑制活性，属于强效的非核苷类抗乙肝病毒天燃产物，可以预期应用于制备治疗乙肝病毒感染疾病的药物。
摘要（英）：

The invention involves A 1- beta-keto-5, 11(13)-diene eudesmane-12-acidum who has the structure as formula (1) shows and its medical salt, or solvate and its drug combinations and its medical usage in reducing hepatitis B surface antgien and inhibiting replication activity of aethyl- hepatovirus HBV-DNA medicinal. The invention compounds has strong inhibitory action in hepatitis B surface antgien(HBsAg) externalized by HepG2.2.15 cells and replication of aethyl- hepatovirus deoxyribonucleotide (HBV-DNA) in vitro, its inhibiting ability against HBsAg surpasses that of positive control Lamivudine in the same dose; it has obvious inhibiting ability against replication of aethyl- hepatovirus HBV-DNA under the concentration of 100 mu g/mL,20 mug/mL and 4 mug/mL DNA, it belongs to anti- aethyl- hepatovirus natural products of superactive non-nucleoside, can be expected for producing drugs for treating aethyl- hepatovirus infected disease.

公开/授权文献
0/0