知搜-全球专利检索

  1. 登录
  2. 注册
发明授权
CN1422950B 表达人类血管紧张素II受体I反义基因的重组腺相关病毒及其制备方法 失效 - 权利终止 复审申请

表达人类血管紧张素II受体I反义基因的重组腺相关病毒及其制备方法
摘要：
一种表达人类血管紧张素II受体I反义基因的重组腺相关病毒(rAAV)，它适用于高血压、心力衰竭、肾脏疾病及其他相关疾病的基因治疗，该载体系统包括包装质粒pXX2，辅助质粒pXX6，真核表达载体pXXUF3内插入了人类血管紧张素II受体I反义基因编码序列。该重组腺相关病毒由天然状态的腺相关病毒经分子生物学方法人工剪切、修饰和加工，再经分子生物学方法包装复制，并经纯化而成。
摘要（英）：

The present invention relates to a virus of reforming grand (rAAV) for expressing reverse gene of blood vessel strain element II receptor I. The virus of reforming grand (rAAV) applies to gene treatment for hypertension, heart failure, kidney illness and other illness relatively. The carrier system comprises packing grain pXX2, assistant grain pXX6, eukaryon expression vector pXXUF3. The pXXUF3 is inserted with reverse gene coding list of blood vessel strain element II receptor. I. The rAAV is sheared, modificated and processed artificially by the natural adenoassociated virus molecular biology method, and is packaged and duplicated by the molecular biology method, thus being made through purification.

公开/授权文献
0/0