知搜-全球专利检索

  1. 登录
  2. 注册
发明公开
CN110706737A 对目标序列进行模拟的方法、装置和电子设备 审中-公开 转让

对目标序列进行模拟的方法、装置和电子设备
摘要：
本申请涉及一种对目标序列进行模拟的方法、装置和电子设备。该方法包括：获取参比序列和待拟合序列；基于目标序列的碱基对应的参比序列的基准参数和待拟合序列的基准参数，获得碱基的比较参数，其中，待拟合序列的基准参数基于多个碱基获得；基于比较参数确定碱基是否合格以获得合格碱基和不合格碱基；对不合格碱基的比较参数进行迭代消减以获得目标参数，迭代消减的迭代次数基于比较参数，且每次迭代消减与至少一个碱基的至少一个比较参数相关联；以及，基于合格碱基和不合格碱基的目标参数确定目标序列的模拟后的序列。这样，可以模拟真实靶向捕获测序数据的参数波动，使模拟数据更加贴近真实。
摘要（英）：

The invention relates to a method and a device for simulating a target sequence, and electronic equipment. The method comprises the following steps of: acquiring a reference sequence and a to-be-fitted sequence; based on the reference parameters of the reference sequence corresponding to bases of a target sequence and the reference parameters of the to-be-fitted sequence to obtain the comparison parameters of the bases, wherein the reference parameters of the to-be-fitted sequence are obtained based on the multiple bases; determining whether the bases are qualified or not based on the comparison parameters to obtain qualified bases and unqualified bases; performing iterative subtraction on the comparison parameters of the unqualified bases to obtain target parameters, wherein the number ofiterations of iterative subtraction is based on the comparison parameters, and each iterative subtraction is associated with at least one comparison parameter of at least one base; and determining the simulated sequence of the target sequence based on the target parameters of the qualified bases and the unqualified bases. Therefore, parameter fluctuation of real targeted capture sequencing data can be simulated, and the simulated data is closer to reality.

0/0