The invention relates to a 3D printing device and method based on centrifugal atomization. Particularly, the 3D printing device comprises a smelting system, a cabin internally provided with a sealingcavity, a rotating disc, a flow guiding sleeve, a three-dimensional motion platform with a molten metal receiving unit and a control unit for controlling the three-dimensional motion platform. Metal raw materials enter the sealing cavity after being molten, are atomized under rotation of the rotating disc and are thrown out circumferentially, only molten metal thrown to a spraying gap of the flowguiding sleeve can be stuck to a receiving unit of a three-dimensional motion platform, the control unit controls the three-dimensional motion platform to move so that the position where the receivingunit receives the molten metal can change to form workpieces of different shapes; in the whole printing process, metal raw materials are directly molten and atomized, then, stacking and solidification are performed, only the solidification speed of the metal raw materials needs to be controlled, and the problems that in the existing 3D technology, the quality of a produced workpiece is low, the material production rate is low, and the equipment cost is high are solved.