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发明授权
CN110294759B HDAC6选择性抑制剂 有权

HDAC6选择性抑制剂
摘要：
本发明涉及HDAC6选择性抑制剂，属于医药技术领域。本发明解决的技术问题是提供一种新的HDAC6选择性抑制剂。本发明HDAC6选择性抑制剂，包括式Ⅰ所示化合物以及药学上可接受的辅料。本发明首次发现式Ⅰ所示化合物能够抑制HDAC6，而对HDAC1和HDAC10的抑制作用很小，因此，可以制备成HDAC6选择性抑制剂，其抑制率高，为HDAC6抑制剂提供了新的选择。
摘要（英）：

The invention relates to an HDAC6 selective inhibitor, and belongs to the technical field of medicine. The to-be-achieved technical purpose is to provide the novel HDAC6 selective inhibitor. The HDAC6selective inhibitor comprises a compound shown in a formula I and a pharmaceutically acceptable auxiliary material. It is found for the first time that the compound shown in the formula I can inhibitHDAC6 while having a small inhibitory effect on HDAC1 and HDAC10, therefore, the HDAC6 selective inhibitor can be prepared, the inhibition rate of the HDAC6 selective inhibitor is high, and a new choice is provided for the HDAC6 inhibitor.

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