The invention provides a warehousing and sorting system capable of achieving full-two-dimensional-code real-time positioning and a sorting method thereof. The warehousing and sorting system comprisesa storage shelf with a multilayer structure, a plurality of cargo loading shelves placed on each layer of storage shelf, at least one AGV trolley placed on each layer of storage shelf, at least one lifting machine arranged on one side of the storage shelf, at least one cargo supplementing channel arranged on one layer of storage shelf and extended to the lifting machine, at least one cargo sortingchannel formed in one layer of storage shelf and extended to the lifting machine, at least one sorting station arranged on one side of the cargo sorting channel, and a plurality of positioning two-dimensional codes which are uniformly distributed on the cargo supplementing channel, the cargo sorting channel and each working surface of each layer of storage shelf. Through the warehousing and sorting system capable of achieving full-two-dimensional-code real-time positioning and the sorting method thereof, automatic warehousing and sorting and intelligent sorting can be achieved; and the manpower cost invested in the sorting process is greatly reduced.