The invention provides a pressure sensor and an electrophysiological catheter. The electrophysiological catheter comprises a catheter far end. The catheter far end is provided with the pressure sensor. The pressure sensor comprises an elastic tube body and at least one strain gauge, a hollowed-out part is arranged on the outer wall of the elastic tube body, and the strain gauges are arranged in the regions except for the hollowed-out part. The strain gauges are arranged in the non-hollowed-out regions of the elastic tube body of the pressure sensor, compared with the mode that the strain gauges are arranged in the hollowed-out region, the precision of acquired electric signals of the strain gauges is high, the interference is low, and the accuracy of measurement of contact force at the catheter far end is greatly improved.