The invention relates to a medical prone mattress. The medical prone mattress comprises a supporting frame, an air bed and gripping devices, wherein the upper end of the supporting frame is provided with the air bed, and the front and rear sides of the left end of the air bed are provided with the gripping devices respectively; each gripping device comprises a gripping connecting plate, a lockingclamping plate, a locking mechanism, a gripping frame, a gripping lower supporting plate, a gripping upper connecting plate, a rotating mechanism, a putting mechanism and a transverse gripping mechanism; the bottom of the left end of the air bed is symmetrically provided with air columns, the air columns are communicated with the air bed, the middle of the left end of the air bed is provided withan inverted-T-shaped groove, the top of the left end of the air bed is provided with an arc-shaped putting cushion, and the middle of the right end of the air bed is provided with an arc-shaped groove. The medical prone mattress can solve the problems that an existing air column bed can be displaced when in use, the feet of a user cannot be assisted or supported, the arms of the user cannot graspor hold the air column bed for supporting, and no supporting exists when the arms of the user are crossed.