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发明公开
CN109971786A 核孔蛋白Nup54及其载体和重组腺病毒的用途 有权

核孔蛋白Nup54及其载体和重组腺病毒的用途
摘要：
本发明提供了核孔蛋白Nup54在制备治疗心肌损伤或者急性心梗的药物中的应用。本发明还提供了一种载体，含有编码核孔蛋白Nup54的基因。还提供了一种重组腺病毒载体，含有编码核孔蛋白Nup54的基因。还提供了一种腺病毒，含有编码核孔蛋白Nup54的基因。还提供了上述载体、重组腺病毒载体、腺病毒在制备治疗心肌损伤或者急性心梗的药物中的应用。通过实验显示，通过核孔蛋白Nup54基因转导，在心梗后，通过调控Serca2a蛋白的核浆转运维持心脏功能，减轻心肌缺血造成的心脏损害，在心梗早期保护心脏功能。
摘要（英）：

The invention provides application of a nucleoporin Nup54 to preparing drugs for treating myocardial damage or acute myocardial infarction, a carrier containing genes coding the nucleoporin Nup54, a recombinant adenovirus carrier containing genes coding the nucleoporin Nup54, an adenovirus containing genes coding the nucleoporin Nup54, and application of the carrier, the recombinant adenovirus carrier and the adenovirus to preparing drugs for treating myocardial damage or acute myocardial infarction. Experiments show that through gene transduction of the nucleoporin Nup54, after myocardial infarction occurs, heart functions are maintained through nucleoplasm transfer of Serca2a proteins, cardiac trauma caused by myocardial ischemia can be reduced, and the heart functions can be protected during the early stage of myocardial infarction.

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