The invention discloses specific nutritional formula food suitable for a tumor patient and a preparation method thereof. The food is mainly prepared from the following raw materials by weight: 15-22 parts of whey protein, 5-10 parts of soybean protein, 2-6 parts of sodium caseinate, 1-3 parts of algae oil, 3-7 parts of medium chain triglyceride, 5-10 parts of vegetable oil, 2-5 parts of arginine,1-8 parts of glutamine, 5-9 parts of polydextrose, 3-7 parts of isomaltooligosaccharide, 6-10 parts of fructose, 15-25 parts of maltodextrin, 0.3-0.6 part of vitamin C sodium, 0.4-1 part of vitamin, 6-10 parts of compound mineral, 0.1-0.2 part of sucralose and 0.3-0.8 part of food essence. The formula food is specially formulated for tumor patients, can supplement the nutrition of the tumor patients, improve immunity and anti-tumor capability and treat tumor diseases radiotherapy and chemotherapy and surgery to recover the body, improve the quality of life and prolong the life cycle. Product color and nutrients can be maintained.