The invention provides a bionic micro-cantilever structure, a manufacturing method thereof and a piezoresistive sensor. The micro-cantilever structure comprises a silicon substrate in a cantilever structure, bionic aperture groups arranged in the silicon substrate, and an on-cantilever piezoresistor, a substrate piezoresistor and an electrode lead arranged on the surface of the silicon substrate;the two bionic aperture groups are arranged symmetrically at the left side and the right side of the center axis of the silicon substrate; the bionic aperture group comprises at least one bionic aperture; the bionic aperture is bionic based on a scorpion seam receptor; and a Wheatstone bridge is formed between the on-cantilever piezoresistor and the substrate piezoresistor through the electrode lead. Based on the mechanism of stress amplification of the seam receptor at a Heterometrus petersii tarsal joint, and in application of a micro-nano manufacturing technology, a micro-cantilever structure with super micro-information sensitivity is designed. The micro-cantilever structure provided in the invention has the characteristics of high sensitivity, high detection accuracy, easy mass production and the like.