The present invention discloses a composition capable of enhancing the drug safety and clinical efficacy of low concentration atropines, and especially when the composition is used in low concentration atropines eye drops, the fact that the composition used in the low concentration atropines eye drops provided by the invention can effectively improve the drug safety of low concentration atropinesby adjusting key quality parameters such as pH, osmotic pressure and viscosity of the eye drops is creatively discovered, especially for improving clinical efficacy, so as to effectively solve the problems in the use of current low-concentration atropines eye drops, such as poor safety, large efficacy differences, unstable main drugs, safety of impurities degradation, concomitant adverse reactionsand other side effects. The composition enhances the clinical efficacy of low concentration atropines eye drops in the prevention and treatment of myopia of adolescents and children and provides a safer and healthier guarantee for the eyesight of adolescents and children, and has a very broad application prospect.