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发明授权
CN109535201B 一种环磷酰胺的合成方法 有权

一种环磷酰胺的合成方法
摘要：
本发明提供一种环磷酰胺的合成方法，通过二氯乙烷，多聚磷酸，醋酐混合溶液中缓慢加入三氯氧磷，滴加3‑氨基丙醇，制得2‑氯‑2‑氧代‑[1.3.2]氧氮磷杂环己烷；加入二氯乙烷和5a分子筛，通入氨气，保持4个大气压下，加热至120℃，反应2‑2.5小时，处理得到环磷酰胺。本发明反应条件相对温和，收率、含量高。
摘要（英）：

The invention provides a synthetic method for cyclophosphoramide. According to the synthetic method, phosphorus oxychloride is slowly added into a mixed solution of dichloroethane, polyphosphoric acidand acetic anhydride, 3-amino propyl alcohol is dropwise added so as to prepare 2-chloro-2-oxo-[1.3.2] oxygen-nitrogen-phosphorus heterocyclic hexane; and dichloroethane and a 5a molecular sieve areadded, ammonia gas is introduced, heating is carried out at 4 atm to reach 120 DEG C, reaction is carried out for 2-2.5 hours, and treatment is carried out so as to obtain the cyclophosphoramide. Themethod has the advantages that the reaction conditions are relatively mild, and the yield and the content are high.

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