The invention aims to disclose a hand-held grabbing tool for an in-core instrument thimble assembly (IITA), which comprises a transmission shaft, an upper guiding seat, a sleeve assembly, a lower guiding seat, a connecting plate and angle steel support legs, wherein the transmission shaft passes through and is fixed on the upper guiding seat by a bearing block, the upper guiding seat is fixed on the upper part of the sleeve assembly, the lower part of the sleeve assembly is fixed on the connecting plate by the lower guiding seat, the lower part of the connecting plate is provided with the angle steel support legs, two sides of the angle steel support legs are symmetrically provided with hook claws, the top of the transmission shaft is provided with a hand wheel, and the bottom of the transmission shaft is provided with a screw, and the screw is connected with a cam through a core rod. Compared with the prior art, the long handle structure is adopted, and the hand wheel is turned manually to open and close the hook claws to grab IITA, which reduces the radiation exposure dose of an operator, and the hook claws are symmetrically arranged, the grabbing is reliable, the positioning isconvenient, the structural design is small and exquisite and compact, the weight is light, the operation is convenient, and assembly and disassembly are easy, thereby achieving the objective of the invention.