The invention discloses a moving mechanism and a mobile robot with the same. The moving mechanism comprises a shell, a sliding base, a movable wheel, an abutting-against part and a deforming part, anda guiding part is arranged in the shell; the sliding base is installed on the guiding part and can move along the guiding part; the mobile wheel is fixed to the sliding base and partially exposed outof the surface of the shell; the abutting-against part abuts against the sliding base and makes the sliding base to move toward the surface of the shell; the deforming part is installed on the shelland connected with the abutting-against part, and when deforming occurs, the acting force with which the sliding base moves toward the surface of the shell is given through the abutting-against part.The robot can adapt to different types of working face movement, especially, when obstacles are encountered, the abutting-against part can give the acting force with which the sliding base slides downwards so that the mobile wheel can get close to a working face to the maximum degree to make contact with the working face and generate friction, and the mobile robot can move and leave from the obstacles.