The invention provides a production system and method of a nano biomedical material. The production system comprises a reactor, a first membrane separator and a second membrane separator; a feeding port of the first membrane separator is communicated with a discharging port of the reactor, and a discharging port of the first membrane separator is communicated with a feeding port of the reactor; afeeding port of the second membrane separator is communicated with the discharging port of the reactor, and a discharging port of the second membrane separator is communicated with the feeding port ofthe reactor. According to the production system and method of the nano biomedical material, the nano biomedical material can be prepared simply through one reactor and two membrane separators, the whole production system is simple, related equipment in the production process of the nano biomedical material is reduced, then the possibility that medicine is contaminated is reduced, thus the improvement of the purity of the nano biomedical material is facilitated, the amount of equipment is reduced, and the reduction of the cost for producing the nano biomedical material is facilitated.