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Invention Publication
CN109200271A 一种蛋白质及其在调控巨噬细胞免疫功能方面的应用 有权

一种蛋白质及其在调控巨噬细胞免疫功能方面的应用
Abstract:
本发明公开了一种蛋白质及其在调控巨噬细胞免疫功能方面的应用，属于生物技术领域。本发明的蛋白质的氨基酸序列如SEQ ID NO.1所示。本发明首次筛选并验证了PvTrag17蛋白在调节巨噬细胞免疫方面的应用，将PvTrag17蛋白作用于未活化的RAW264.7巨噬细胞，可显著增强RAW264.7巨噬细胞分泌NO、IL-2、IL-6、TNF-α的能力，使IL-6、TNFα、IL-2和iNOS的mRNA水平分别上调6.9倍～11.89倍，具有广阔的应用前景。
Abstract(English):

The invention discloses a protein and an application thereof in regulating macrophage immune function, belonging to the field of biotechnology. The amino acid sequence of the protein of the present invention is shown in SEQ ID NO. 1. The invention screens and verifies the application of PvTrag17 protein in regulating macrophage immunity for the first time. When the PvTrag17 protein is applied to the inactivated RAW264.7 macrophage, the secretion of NO, IL by the RAW264.7 macrophage can be significantly enhanced. 2, IL-6. TNF ALPHA The ability of alpha to make IL-6. TNFALPHA , IL- 2 and iNOS mRNA levels are up-regulated by 6.9-11.89 folds, respectively.

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