The invention provides a high power supply rejection ratio depletion reference voltage source. The high power supply rejection ratio exhaustion reference voltage source comprises NMOS tubes M1, M2, M3, M4, M5, M6, and M7, a resistor R1 and a capacitor C1. An electric current generated by the depletion-mode NMOS tube M3 is enabled to act on the enhancement-mode NMOS tube M4, and VGS of the enhancement-mode tube M4 is generated. On the basis of a traditional depletion reference, two groups of three-stage sleeve depletion-mode tube structures of the depletion-mode NMOS tubes M1, M2, and M3 and M5, M6 and M7 are used, a power supply rejection ratio of a voltage reference is improved, a frequency range of the high power supply rejection ratio is extended, and a soft start circuit is designed onthe basis, thereby a purpose of gentle electrification of the reference voltage is achieved.