The invention discloses monophosphine ligand based on a tetramethyl spirobiindane skeleton, as well as an intermediate, a preparation method and application thereof. The monophosphine ligand adopts acompound with a structure as shown in a general formula I or I' or an enantiomer, a racemate or a diastereoisomer of the compound, and comprises phosphorous ester ligand, phosphorous ester ligand, phosphoramidite ester ligand, phosphoric acid and phosphamide. The monophosphine ligand takes a known 3, 3, 3', 3'-tetramethyl-1, 1'-spirobiindane-7, 7'-dimethyl aldehyde as a raw material, and is formedthrough a formula II which is taken as a preparation route of a key intermediate. The novel monophosphine ligand can serve as ligand to be used for organic reaction of metal catalysis or be directlyused for catalyzing the organic reaction, can particularly serve as chiral monophosphine ligand to be widely applied to multichiral catalytic reaction including asymmetric addition, asymmetric hydrogenation, asymmetric coupling and asymmetric allylic alkylation, and has economical practicability and an industrial application prospect.