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发明公开
CN108586335A 2-羟基苯甲酰胺-1,2,3,4-四氢异喹啉-O-氨基甲酸酯化合物及其制备方法 失效 - 权利终止

2-羟基苯甲酰胺-1,2,3,4-四氢异喹啉-O-氨基甲酸酯化合物及其制备方法
摘要：
本发明属于有机合成技术领域，具体涉及一种2-羟基苯甲酰胺-1,2,3,4-四氢异喹啉-O-氨基甲酸酯化合物及其制备方法，其化学结构通式如(I)所示。本发明化合物对乙酰胆碱酯酶和丁酰胆碱酯酶均具有显著抑制作用，对金属离子有强络合作用，具有强抗氧化活性，对Aβ1-42诱导的SH-SY5Y细胞损伤有显著的保护作用，对过氧化氢诱导的PC12细胞损伤有显著的保护作用。
摘要（英）：

The invention belongs to the technical field of organic synthesis, and particularly relates to a 2-hydroxybenzamido-1,2,3,4-tetrahydroisoquinolyl-O-carbamate compound and a preparation method thereof.The 2-hydroxybenzamido-1,2,3,4-tetrahydroisoquinolyl-O-carbamate compound adopts a chemical structural formula as shown in a formula (I). The 2-hydroxybenzamido-1,2,3,4-tetrahydroisoquinolyl-O-carbamate compound has a significant inhibiting effect on both acetylcholinesterase and butyrylcholinesterase, has a strong complexing effect on metal ions, has strong antioxidant activity, has a significant protective effect on Abeta1-42-induced SH-SY5Y cell damage and has a significant protective effect on hydrogen peroxide-induced PC12 cell damage.

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