The invention provides a method and device for communication between a mobile terminal and a self-defined 2.4G wireless device. The method comprises the following steps: constructing a first BLE datapacket of which a protocol data unit bears a first 2.4G data packet; sending the first BLE data packet to a self-defined 2.4G wireless device, so that the self-defined 2.4G wireless device can executea corresponding control operation according to a control command carried by the first 2.4G data packet; receiving a second BLE data packet which is sent by the self-defined 2.4G wireless device and is borne in a second 2.4G data packet protocol data unit; obtaining a response operation of the self-defined 2.4G wireless device to the control command according to a response command carried by the second BLE data packet, wherein the protocol data unit of the first 2.4G data packet carries a control command of operating the self-defined 2.4G wireless device, and the protocol data unit of the second BLE data packet carries a response command of the control command. According to the method and the device in the invention, the implementation cost for controlling the self-defined 2.4G wireless device through the mobile terminal and the power consumption of the self-defined 2.4G wireless device can be reduced.