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发明公开
CN108440405A 一种烟酰胺与苯甲酸的共晶产品及结晶方法 无效 - 驳回

一种烟酰胺与苯甲酸的共晶产品及结晶方法
摘要：
本发明涉及一种烟酰胺与苯甲酸的共晶产品及结晶方法。晶体态产品X射线粉末衍射在衍射角2θ＝4.5±0.1,8.9±0.1,13.6±0.1,14.3±0.1,16.3±0.1,18.1±0.1,19.6±0.1,22.6±0.1，23.1±0.1和25.4±0.1,26.4±0.1,26.9±0.1度处有特征峰。在搅拌条件下，将烟酰胺于40～60℃下加到有机溶剂中；搅拌使固体完全溶解；将与烟酰胺等质量的苯甲酸加入到溶液中溶解完全，继续恒温搅拌使苯甲酸与烟酰胺反应完全；降温到5～15℃；养晶、晶浆洗涤、过滤、干燥，得到共晶产品。产品色泽白，粒度分布匀，结晶过程单程收率85％以上。
摘要（英）：

The invention relates to a eutectic product of nicotinamide and benzoic acid and a crystallization method. A crystalline-state product X-ray powder has characteristic peaks when being diffracted at diffraction angles 2 theta of 4.5+/-0.1, 8.9+/-0.1, 13.6+/-0.1, 14.3+/-0.1, 16.3+/-0.1, 18.1+/-0.1, 19.6+/-0.1, 22.6+/-0.1, 23.1+/-0.1, 25.4+/-0.1, 26.4+/-0.1 and 26.9+/-0.1. The crystallization methodcomprises the following steps: under a stirring condition, adding the nicotinamide into an organic solvent at the temperature of 40 to 60 DEG C; stirring to completely dissolve a solid; adding the benzoic acid with the mass equal to the nicotinamide into a solution and completely dissolving; continually stirring at constant temperature to enable the benzoic acid and the nicotinamide to react completely; cooling to 5 to 15 DEG C; carrying out crystal growth, washing crystal slurry, filtering and drying to obtain the eutectic product. The product has white color and luster and uniform granularity distribution; the one-way yield in a crystallization process reaches 85 percent or above.

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