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发明授权
CN108440389B 3,4,5-三羟基苯甲酸衍生物及其制备方法与应用 有权

3,4,5-三羟基苯甲酸衍生物及其制备方法与应用
摘要：
本发明提供了一种3,4,5‑三羟基苯甲酸衍生物及其制备方法与应用，所述化合物具有如下通式I或II所示的结构。本发明还涉及该类衍生物的制备方法。活性测试结果表明，本发明大部分3,4,5‑三羟基苯甲酸衍生物表现出显著的HIV‑1 RNase H抑制活性，说明该类化合物作为一系列结构新颖的HIV‑1 RNase H制剂，具有进一步的研究价值。因此，本发明还涉及该类衍生物作为HIV抑制剂在制备抗艾滋病药物中的应用。
摘要（英）：

The invention provides 3, 4, 5-trihydroxybenzoic acid derivatives. The compounds have structures shown as the following general formula I or II. The invention further relates to preparation methods ofthe derivatives. Activity testing results show that most derivatives present remarkable HIV-1 RNase H inhibiting activity, it shows that the compounds serving as a series of HIV-1 RNase H inhibitingpreparations novel in structure have further research value. Therefore, the invention further relates to application of the derivatives serving as HIV inhibitors in preparing anti-AIDS drug.

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