The invention discloses a diaphragm plate frame filter press cleaning method. The diaphragm plate frame filter press cleaning method comprises the following steps: 1) washing the surface of a filter cloth by using in-situ water washing; 2) conveying a first cleaning agent into a plate frame machine through a sludge inlet pipeline of the plate frame machine, simulating the sludge feeding process into a filter pressing chamber, and enabling the first cleaning agent to walk once along the flow of the sludge filtrate, the filter pressing machine chamber needing to be filled with the first cleaningagent, washing the filter cloth and the pipeline; 3) conveying the reclaimed water to the back of the filter cloth of the plate frame machine through the pipeline of the filtrate bottom of the plateframe machine, and reversely passing through the filtrate pipeline, allowing the reclaimed water to pass through the back of the filter cloth and carrying the pollutants intercepted on the filter cloth, and discharging water from the upper pipeline; 4) adopting a second cleaning agent to enter from the lower side filtrate pipeline of the plate frame machine, flowing out of the upper side pipeline,and carrying out reverse soaking and cleaning on the filter cloth; 5) and cleaning the surface of the filter cloth by using in-situ water washing so as to flush the intercepted substances dissolved in the backwashing process. According to the invention, the intercepted substances of the filter cloth are reduced, and the water filtering capacity of the filter cloth is improved.