The invention relates to the field of suspension cables of bridge parts, in particular to an aluminium-clad steel wire main cable strand and a manufacturing method thereof. The aluminium-clad steel wire main cable strand comprises cable wires (11), wherein the cable wires (11) are steel wires. The aluminium-clad steel wire main cable strand is characterized by further comprising anti-corrosion layers (12), winding bridles (2), concrete anchors (3) and casting materials (4); the winding bridles (2) are wound around the outer side faces of cable bunches (1), and after being scattered, the cablewires (11) at the two ends of the cable bunches (1) are sleeved into the concrete anchors (3) respectively. The manufacturing method of the aluminium-clad steel wire main cable strand is characterizedby sequentially including the following steps of a, standard formulating; b, wire releasing; c, stretch-drawing; d, bunch collecting; e, winding; f, cutting-off; g, acid pickling; h, cleaning; i, anchoring; j, pouring; k, looping. The aluminium-clad steel wire main cable strand is convenient to manufacture, excellent in anti-corrosion performance and long in service life.