The invention relates to a pressing positioning device for pipe winding. The pressing positioning device is characterized by comprises a base frame provided with a bottom plate and a top plate which can be opened and closed relatively, a pressing wheel which is arranged in the base frame and can rotate around a first rotary shaft arranged in the center of the pressing wheel, a positioning wheel which is arranged in the base frame and can rotate around a second rotary shaft arranged in the center of the positioning wheel, and a tensile force adjusting device which is connected between the top plate and the bottom plate and used for adjusting the pressure of the pressing wheel and the positioning wheel on a heat exchange pipe, wherein the first rotary shaft is supported on the top plate; thesecond rotary shaft is supported on the bottom plate; the positioning wheel is located under the pressing wheel and provided with a peripheral positioning groove; and a space allowing the heat exchange pipe to penetrate through is formed between the pressing wheel and the positioning groove of the positioning wheel. Compared with the prior art, accurate thread pitch positioning of the heat exchange pipe and proper tensioning force can be provided, the structure is simple, and all parts are easy and convenient to replace.