The invention discloses end cover glue sealing and pressing jointing equipment and a pressing jointing method thereof. The pressing jointing equipment comprises a rack provided with an operation platform, a guide rail fixed to the rack, a pressing jointing assembly, a driving device, a locking device and a positioning device; the pressing jointing assembly is connected to the guide rail in a sliding manner and comprises a first pressure plate assembly and a second pressure plate assembly which are arranged front and back along the pressing jointing stroke and can move relatively, the first pressure plate assembly is used for applying pressure to workpieces, and the second pressure plate assembly is used for avoiding axial displacement of the workpieces during pressing jointing; the drivingdevice is arranged on the rack, is connected with the first pressure plate assembly and is used for driving the first pressure plate assembly to slide along the guide rail to apply the pressure to the workpieces; the locking device is connected with the second pressure plate assembly and is used for fixing the second pressure plate assembly to the rack after the position of the second pressure plate assembly relative to the rack is adjusted; and the positioning device is arranged on the operation platform in a lifting manner in the mode of being parallel to the guide rail. The two pressure plate assemblies arranged front and back are both connected to the guide rail, the locking device and the positioning device are arranged, operation is easy in the pressing jointing process, the work isstable, and products obtained through pressing jointing are excellent.