The invention belongs to the technical field of driving of RS422 communication of a CPCI bus, and discloses an interrupt-based driving method for the RS422 communication of the CPCI bus in an XP system. A system which the method is based on comprises a Windows xp underlying driver, an inf file and a dll program; an IoConnectInterrupt function interface provided by a Windows DDK (driver developmentkit) is called through the Windows XP underlying driver to realize communication of a receiving mode of a terminal; the method provided by the invention solves the problem of long data communicationtime, provides an interrupt receiving mode driver and API function access for a newly researched and developed RS422 communication board card, and realizes function testing; and the method is used ina complex product batch production process, so that the same-type device driving can be realized by only few modifications.