The invention discloses a preparation method of fructus trichosanthis tea vinegar beverage with blood fat reducing effect. The preparation method comprises the following steps: adding a proper amountof water into fructus trichosanthis, green tea, shaddock peel and jasmine flowers, performing reflux extraction, collecting reflux liquid and performing nanofiltration concentration on the collected reflux liquid to obtain aromatic extracting liquid for future use; mixing fructus trichosanthis pulp, shaddock, white sugar, onion, mung beans and a proper amount of water uniformly, steaming, inoculating acetic acid bacteria, sealing a cover and performing fermentation for 18 to 20 days, adjusting the total acid content of the material liquid obtained after fermentation, filtering to vinegar liquid and performing cold storage for future use; and mixing the aromatic extracting liquid, the vinegar, honey, apple juice and a proper amount of water uniformly and homogenizing to obtain the fructus trichosanthis tea vinegar beverage. The vinegar, which is produced by taking sweet water obtained by mixing the fructus trichosanthis pulp, the onion, the mung beans and the like as an acetic acid bacterium culture medium and performing fermentation, has good blood fat reducing effect and is health-care; and the aromatic substance obtained after extraction reflux, concentration and nanofiltration and the vinegar are mixed, so that the fructus trichosanthis tea vinegar beverage has mellow fragrance and neutralizes the pungent odor of the vinegar.